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Study suggests new potential strategy to fight against pancreatic cancer

A University of Michigan-led study is shedding new light on the way pancreatic cancer cells turn nearby connective tissue cells into co-conspirators in their deadly growth. The findings, which appear in Nature Metabolism, also suggest a new potential strategy against pancreatic cancer by identifying critical components of metabolic cross talk between cells that might be attacked […]

Ipsen scores FDA fast-track for Onivyde in first-line pancreatic cancer

The FDA designation will review the use of Onivyde (liposomal irinotecan) in combination with 5- fluorouracil/leucovorin (5-FU/LV) and oxaliplatin (OX), also known as Nalirifox, in patients with previously untreated, unresectable, locally advanced and metastatic pancreatic ductal adenocarcinoma (PDAC). The fast-track programme aids the development and also expedites the review of drugs that are designed to treat serious […]

Revealed: How cancer develops resistance to treatment

Cancer cells can turn on error-prone DNA copy pathways to adapt to cancer treatment, a breakthrough study published in the journal Science has revealed. Bacteria use the same process, termed stress-induced mutagenesis, to develop antibiotic resistance. The cells of the human body are constantly dividing, and each time need to copy a three billion-letter DNA […]

$5.75M grant to help researchers study role of obesity in development of pancreatic cancer

A team of researchers from the UCLA Jonsson Comprehensive Cancer Center and peer institutions has been awarded a $5.75 million grant from the National Cancer Institute to study the correlation between obesity, inflammation and pancreatic cancer. The scientists hope their findings may help people avoid getting this cancer. “We know that the biological mechanisms of […]

Chemotherapy prior to surgery may help outcomes for patients with pancreatic cancer

A clinical trial led by researchers from the University of Cincinnati has found that one-third of patients receiving chemotherapy before surgery for pancreatic cancer had very encouraging results at the time of the procedure. The results of this National Cancer Institute’s SWOG Cancer Research Network trial will be presented as part of the ASCO20 Virtual […]

Why pancreatic ductal adenocarcinoma is so lethal

Pancreatic ductal adenocarcinoma (PDA) is a deadly cancer, killing patients within a year. CSHL Professor Christopher Vakoc and his former postdoc Timothy Somerville discovered how pancreatic cells lose their identity, acquire a deadly new identity, and recruit nearby cells to help them grow, promote inflammation, and invade nearby tissues. This understanding could lead to new therapies […]

Another Step Towards Earlier Detection of Pancreatic Cancer

— Risk-prediction model uses biomarkers added to clinical and genetic risk factors A risk-prediction model combining genetic and clinical factors with circulating biomarkers can identify people at notably higher than normal risk of pancreatic cancer who could benefit from screening and early detection, a U.S. nested case-control analysis suggested. The study’s final integration of three […]

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