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Antihypertension drug losartan may improve treatment of ovarian cancer

A new study from a Massachusetts General Hospital (MGH) research team has found that the hypertension drug losartan, which targets the angiotensin signaling pathway, may improve the effectiveness of chemotherapy agents used to treat ovarian cancer. Previous research from the same team identified a similar effect for losartan in animal models of breast and pancreatic cancer, […]

VISTA checkpoint implicated in pancreatic cancer immunotherapy resistance

Researchers have identified a new potential immunotherapy target in pancreatic cancer, which so far has been notoriously resistant to treatment with immune checkpoint blockade drugs effective against a variety of other cancers. The University of Texas MD Anderson Cancer Center research team found overexpression of the immune checkpoint VISTA on immune cells, especially macrophages, that […]

Adjuvant Therapy Questioned for Patients With Small Pancreatic Tumors

Patients with early stage pancreatic ductal adenocarcinoma (PDAC) may not benefit from adjuvant therapy after surgery if the tumor is smaller than 1 cm, according to a retrospective analysis publishedin Cancer. Although the study indicates a change in the standard of care may be necessary for patients with particularly small tumors, additional studies are needed to validate […]

Trial will test MRI-guided radiation for advanced pancreatic cancer

Researchers are testing the use of a procedure that uses stereotactic MRI imaging to guide treatment of advanced pancreatic cancer. The initiative was announced by ViewRay, a Cleveland-based vendor that manufacturers the radiation therapy system used to deliver the system that enables precise treatment of cancer patients through the use of advanced imaging technology.The company […]

Healthy diet, exercise has positive impact on surgical recovery, study finds

 If you or a loved-one are going under the knife anytime soon, scientists suggest thinking about walking a couple miles every day or eating more greens leading up to your procedure. According to a new study conducted by the University of Washington School of Medicine, “Pre-hab” is the new “rehab.” Dr. Venu Pillarisetty, associate professor of surgery at […]

Study shows benefits of vitamin C in treating cancer

Although the use of intravenous vitamin C by those with a diagnosis of cancer is considered, by traditional medicine, an ineffective and possibly dangerous therapy, there is accumulating medical research that intravenous vitamin C may improve outcomes. A recent medical study evaluating the effect of adding intravenous vitamin C during chemotherapy for pancreatic cancer demonstrated […]

Augmenting T-Cell Immunity in Pancreatic Cancer

Stephanie K. Dougan, PhD, assistant professor, Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, researcher, Dana-Farber Cancer Institute, discusses ways of augmenting T-cell immunity in pancreatic cancer. The current standard of care for patients with pancreatic cancer is combination chemotherapy, such as FOLFIRINOX or gemcitabine and nab-paclitaxel (Abraxane). However, the prognosis remains poor, notes […]