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Rafael Pharmaceuticals Reaches Milestone of 100 Patients Enrolled in Pivotal Phase 3 Trial (AVENGER 500) of CPI-613®️ (devimistat) for Patients with Metastatic Pancreatic Cancer

 Rafael Pharmaceuticals, Inc. (“Rafael” or the “Company”), a leader in the growing field of cancer metabolism-based therapeutics, today announced that it has enrolled 100 patients in its pivotal Phase 3 clinical trial for metastatic pancreatic cancer (AVENGER 500). The multicenter, open-label, randomized trial is evaluating the efficacy and safety of Rafael’s lead compound CPI-613®️ (devimistat) in […]

Response rate to albumin-bound paclitaxel plus gemcitabine plus cisplatin treatment among patients with advanced pancreatic cancer: A phase 1b/2 pilot clinical tria

 Adding a drug that targets a molecular vulnerability in pancreatic cancer could provide substantial benefit to patients, according to a clinical trial study by the HonorHealth Research Institute and the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, in conjunction with the Pancreatic Cancer Research Team and Cancer Research And Biostatistics. Published […]

Drug Trio Improves Odds Against Advanced Pancreatic Cancer

A three-drug chemo cocktail appears to shrink tumors and improve survivorship among pancreatic cancer patients, a new, small study shows. Tumors substantially shrank for just over 71% of patients treated with a three-drug regimen of nab-paclitaxel, gemcitabine and platinum-based cisplatin, the researchers found. Further, 16 patients (64%) out of the 25 treated were still alive […]

Fungal Invasion of Pancreas Creates Cancer Risk

Certain fungi move from the gut to the pancreas, expand their population more than a thousand-fold, and encourage pancreatic cancer growth, a new study finds. Published online in Nature October 2, the study is the first to offer strong evidence that the mycobiome—the local mix of fungal species in the pancreas—can trigger changes that turn normal cells into pancreatic […]

A compound may improve pancreatic cancer survival rate, scientists find

Scientists have discovered a compound could help slow down pancreatic cancer by targeting proteins that promote metastatic cells. Researchers at Johns Hopkins Medicine found that the compound, 4-HAP, reduced tumors in mice and could improve survival for pancreatic cancer patients. According to the National Cancer Institute, 73,554 people in the U.S. have pancreatic cancer and […]

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