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Finding Clinical Trials

 A clinical trial is a research study designed to evaluate a new cancer treatment. Patients enrolled in a clinical trial are among the first to receive new treatments before they become widely offered.

Latest News

Pancreatic Cancer May Be Accelerated by Stress, Finds Study Findings suggest beta-blockers, which inhibit stress hormones, may increase survival

A new study shows that stress accelerates the development of pancreatic cancer by triggering the release of “fight-or-flight” hormones. Beta-blockers—commonly used medications that inhibit these hormones—were found to increase survival in a mouse model of the disease. An additional analysis of patients with advanced pancreatic cancer revealed that those who were taking beta-blockers for another condition lived approximately two-thirds longer than those who were not taking the medications.

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Von Hoff's Quest Is for a Cure in Pancreatic Cancer

MaryAnna set the pattern: One of Von Hoff’s earliest memories is sitting on her lap, listening to her read Aesop’s fables each day. In his mid-90s, Stanley was still cutting his neighbor’s lawn and growing vegetables. Just as his father had apprentices, so, too, did Von Hoff, who has taught what he knows to those who came up after him. Sharing Knowledge on a Larger Scale Von Hoff shows immense gratitude for the many people he has learned from, as well as the many he’s had the opportunity to mentor. His curriculum vitae spans 200 pages, including committees, societies, and honors, as well as the postdoctoral candidates he has mentored.His biggest accomplishment, he said, has been the establishment of the AACR-ASCO Methods in Clinical Cancer Research course, a collaboration between the 2 societies.

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More tumor mutations equals higher success rate with cancer immunotherapy drugs

The mutational burden, or the number of mutations present in a tumors DNA, is a good predictor of whether that cancer type will respond to a class of cancer immunotherapy drugs known as checkpoint inhibitors, a new study led by Johns Hopkins Kimmel Cancer Center researchers shows. The finding, published in the Dec. 21 New England Journal of Medicine, could be used to guide future clinical trials for these drugs.Checkpoint inhibitors are a relatively new class of drug that helps the immune system recognize cancer by interfering with mechanisms cancer cells use to hide from immune cells. As a result, the drugs cause the immune system to fight cancer in the same way that it would fight an infection.

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Study Prompts New Ideas on Cancers’ Origin

Rapidly dividing, yet aberrant stem cells are a major source of cancer. But a new study suggests that mature cells also play a key role in initiating cancer, a finding that could upend the way scientists think about the origins of the disease.Researchers at Washington University School of Medicine in St. Louis have found that mature cells have the ability to revert back to behaving more like rapidly dividing stem cells.

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Regular Use of Aspirin or Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs Is Not Associated With Risk of Incident Pancreatic Cancer in Two Large Cohort Studies.

In the prospective cohort study, 1122 participants developed pancreatic adenocarcinoma over 4.2 million person-years. Use of aspirin or non-aspirin NSAIDs was not associated with pancreatic cancer risk, even after considering several latency exposure classifications. In a pre-planned subgroup analysis, regular aspirin use was associated with reduced pancreatic cancer risk among participants with diabetes (relative risk, 0.71; 95% CI, 0.54-0.94). In the nested case-control study, pre-diagnosis levels of salicylurate were not associated with pancreatic cancer risk (odds ratio, 1.08; 95% CI, 0.72-1.61; Ptrend 0.81; comparing participants in the highest quintile to those in the lowest quintile of plasma salicylurate).

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How inhibiting one protein could help to treat pancreatic cancer

Targeting an enzyme that makes pancreatic cancer cells more aggressive by silencing some of their genes could make the deadly disease less resistant to treatment. red-colored pancreas in x-ray Could the findings of a new study help in the fight against pancreatic cancer? This was the conclusion of new research from Genentech, a biotechnology company in South San Francisco, CA, which was recently reported in the Journal of Cell Biology.

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TGen and Baylor poised to create early detection test for pancreatic cancer

A group of the nation's premier cancer researchers led by the Baylor Scott & White Research Institute (BSWRI) and the Translational Genomics Research Institute (TGen) -- has secured a $5.13 million federal grant to develop an early detection system for pancreatic cancer, the nation's third-leading cause of cancer-related death.Because it displays no overt symptoms or pain in its early stages, pancreatic cancer often is not diagnosed until it has spread to other organs, especially the liver and the lungs

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Michael G. Goggins, MBBCH, MD, is professor of pathology, medicine and oncology at the Johns Hopkins University School of Medicine. He serves as director of the Pancreatic Cancer Early Detection Laboratory and is an attending physician in medicine in the Division of Gastroenterology and Hepatology at The Johns Hopkins Hospital, as well as a molecular biologist.

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Identifying Unique Antigen Qualities in Long-Term Pancreatic Cancer Survivors

Vinod P. Balachandran, MD, Surgical Oncologist, Memorial Sloan Kettering Cancer Center, discusses an analysis to determine the unique antigen qualities of long-term survivors of pancreatic cancer during The Society for Immunotherapy of Cancer (SITC) 32nd Annual Meeting.

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Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma

Are alterations in the 4 main driver genes for pancreatic adenocarcinoma associated with patient outcomes after pancreatic cancer resection? In this study involving 356 patients with resected pancreatic adenocarcinoma, immunohistochemistry and next-generation DNA sequencing of formalin-fixed, paraffin-embedded pancreatic adenocarcinoma resection specimens identified alterations in the 4 main driver genes (KRAS, CDKN2A, SMAD4, and TP53). Disease-free survival and overall survival were associated with the presence and pattern of alterations in these 4 genes independent of previously identified prognostic factors.

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Lustgarten Foundation Launches Online Support Community

Today the Lustgarten Foundation for Pancreatic Cancer Research in partnership with Let’s Win, an initiative supported by the Foundation, and Inspire launched an online support community, Pancreatic Cancer Connections, which provides a safe space for pancreatic cancer patients and their loved ones to share their experiences, get valuable coping resources, and support one another. Inspire is a leading healthcare social network that connects more than 1,000,000 patients and caregivers.

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Thousands Walk at Jones Beach to fight pancreatic cancer

The rain didn't stop people from taking steps to push for earlier detection, better treatment and a cure for the disease, which often goes undetected until it's in its advanced stages.

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Genetic test successfully detects some asymptomatic pancreatic cancers

A genetic test developed at UPMC proved highly sensitive at determining which pancreatic cysts are most likely to be associated with one of the most aggressive types of pancreatic cancer, UPMC and University of Pittsburgh School of Medicine scientists reported in Gut, the journal of the British Society of Gastroenterology.The successful results are a critical step toward a precision medicine approach to detecting and treating pancreatic cancer, which has one of the lowest survival rates of all cancers.

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Surgery for pancreatic cancer: critical radiologic findings for clinical decision making

Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States, with an estimated 53,670 new cases diagnosed and an estimated 43,090 deaths in 2017. This high mortality rate is in part due to the small percentage of patients diagnosed with local disease, as well as the biologically aggressive nature of the disease. While only 10–20% of patients will present with surgically resectable disease, this is the only possible curative therapy. 


How Bacteria Hinder Chemotherapy

To the reasons that chemotherapy sometimes does not work, we can now add one more: bacteria. In a study published in Science, researchers describe findings that certain bacteria can be found inside human pancreatic tumors. The findings further showed that some of these bacteria contain an enzyme that inactivates a common drug used to treat various cancers, including pancreatic cancer. Working with mouse models of cancer, they demonstrated how treatment with antibiotics on top of chemotherapy may be significantly superior to treatment with chemotherapy alone.


NCCN Flash Update: Pancreatic Adenocarcinoma

NCCN has published updates to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) and the NCCN Drugs & Biologics Compendium (NCCN Compendium®) for Pancreatic Adenocarcinoma. These NCCN Guidelines® are currently available as Version


Let’s Win an initiative of the Lustgarten foundation, Inducted into the PR News Platinum Hall of Fame


Clinical and Genetic Implications of DNA Mismatch Repair Deficiency in Patients With Pancreatic Ductal Adenocarcinoma/h4>

DNA mismatch repair status is a well-established biomarker in colorectal cancer and is associated with both a favorable prognosis and excellent response to immunotherapy.1 However, the influence of deficient DNA mismatch repair (dMMR) and microsatellite instability in pancreatic ductal adenocarcinoma (PDAC) remains unknown. The prognosis of PDAC is typically dismal and treatment options are limited, but previous research has suggested that microsatellite instability in resected PDAC specimens may be associated with improved survival


Study pinpoints gene’s new role in pancreatic cancer

Pancreatic cancer is a particularly deadly form of disease, and patients have few options for effective treatment. But a new Yale-led study has identified a gene that is critical to pancreatic cancer cell growth, revealing a fresh target for new therapies. Senior author Narendra Wajapayee, associate professor of pathology, and his research team started with the premise that cancer cells need specific nutrients to survive and divide quickly. They searched gene data sets to find genes involved in metabolism regulation that were highly expressed in pancreatic cancer tissue compared to normal pancreatic tissue. Out of 13 metabolic genes identified, they narrowed their search to four that when blocked.


New SU2C-Lustgarten Foundation team aims to apply CAR T-cell therapy to pancreatic cancer

Stand Up To Cancer is supporting a new translational research team to explore how a type of immunotherapy that has been very successful in blood cancers can be applied to pancreatic cancer, the American Association for Cancer Research, SU2C's Scientific Partner, announced today. The approach is called chimeric antigen receptor (CAR) T-cell therapy, which uses specially modified immune cells to find and destroy cancerous cells.

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Partnering Cells Turn Off Immune Attack on Pancreatic Tumors

Two cell types work together to protect pancreatic tumors from destruction by the immune system. But, blocking this partnership may restore the system's ability to attack these same tumor cells.These are the findings of a study in mice led by researchers from NYU Langone Medical Center and its Perlmutter Cancer Center, and published online July 18 in Cell Reports.The study results revolve around the immune system, which is designed to attack invaders like viruses

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Perlmutter Cancer Center at NYU Langone has announced the creation of a multidisciplinary center of excellence to develop innovative approaches to diagnose, treat and prevent pancreatic cancer.The new Pancreatic Cancer Center brings together laboratory researchers, surgeons, oncologists, geneticists and others throughout NYU Langone to create a comprehensive care model to address this usually fatal disease, projected to be the second leading cause of cancer death by 2020.


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Intezyne Technologies Granted Orphan Drug Designation for IT-139 in Pancreatic Cancer

ntezyne Technologies, a clinical-stage biopharmaceutical company developing novel anti-cancer therapies, announced that that the Office of Orphan Products Development of the Food and Drug Administration (FDA) has granted Orphan Drug Designation (ODD) to IT-139, the most clinically advanced GRP78 inhibitor in development for solid tumors, for the treatment of pancreatic cancer.

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Halozyme Phase 2 Data In Advanced Pancreas Cancer Featured In An Oral Presentation At ASCO'

Encouraging results from a Phase 2 randomized, multi-center clinical trial in pancreas cancer patients conducted by Halozyme Therapeutics (NASDAQ: HALO) were presented today at the American Society of Clinical Oncology (ASCO) annual conference. Principal Investigator Sunil R. Hingorani, M.D., Ph.D., a pancreas cancer expert at Fred Hutchinson Cancer Research Center and professor at University of Washington School of Medicine expanded on findings from patient data as of December 2016 in the HALO-202 study of investigational new drug, PEGPH20 (pegvorhyaluronidase alpha) in combination with ABRAXANE® (nab-paclitaxel) and gemcitabine.

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Painless cancer detection could become routine thanks to 'liquid biopsies'

Researchers are developing tests that could make cancer detection so painless that it becomes part of routine check-ups, experts said, as new developments in such “liquid biopsy” technology were presented at the world’s largest cancer conference in Chicago this weekend.

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New test may improve pancreatic cancer diagnoses

Pancreatic cancer is hard to detect early, when the disease is most amenable to treatment. But a new study describes a blood test that may aid the diagnosis of pancreatic cancer and someday make earlier screening feasible, the authors say. The test detects a combination of five tumor proteins that appear to be a reliable signature of the disease, the researchers report in the May 24 Science Translational Medicine.

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FDA Approves First Immunotherapy Treatment for Pancreatic Cancer

In an unprecedented and expedited review, the Food and Drug Administration (FDA) approved the use of pembrolizumab for pancreatic cancer patients with microsatellite instability. The Lustgarten Foundation played a critical role in bringing this new treatment to patients.


Scientists unveil new blood test to detect pancreatic cancer

Scientists unveiled a test Monday for detecting pancreatic cancer, one of the deadliest forms, in less than a drop of blood. The diagnostic method is fast, cheap and ultra-sensitive, and can be adapted to test for other diseases whose fingerprints are detectible in blood, they wrote in the journal Nature Biomedical Engineering.


Pancreatic tumors rely on signals from surrounding cells

LA JOLLA--Just as an invasive weed might need nutrient-rich soil and water to grow, many cancers rely on the right surroundings in the body to thrive. A tumor's microenvironment--the nearby tissues, immune cells, blood vessels and extracellular matrix--has long been known to play a role in the tumor's growth. Now, Salk scientists have pinned down how signals from this microenvironment encourage pancreatic tumors to grow by altering their metabolism. Blocking the pathways involved, they reported in Proceedings of the National Academy of Sciences the week of January 16, 2017, can slow the growth of a pancreatic cancer.


Caris Life Sciences and the Lustgarten Foundation Collaborate to Support Immunotherapy Clinical Trial for Pancreatic Cancer

Caris Life Sciences, a leading innovator in molecular science, and the Lustgarten Foundation, the largest private funder of pancreatic cancer research, are collaborating to support a clinical trial evaluating the impact of immunotherapy in the treatment of pancreatic cancer. Caris is providing clinical trial enrollment services to identify potential trial candidates based on biomarker expression results and facilitate communication between treating physicians and study investigators. The Lustgarten Foundation is a sponsor of the study for pancreatic cancer patients in support of its mission to advance scientific and medical research related to the diagnosis, treatment and cure of pancreatic cancer. While pancreatic cancer is an extremely challenging disease to treat, recent advances in immunotherapies are rapidly changing the way cancer is being treated. The study, "Phase 2 Study of MK-3475 in Patients with Microsatellite Unstable (MSI) Tumors (NCT01876511)," is investigating whether MK-3475, an immunotherapy that blocks negative signals to T cells, is an effective anti-tumor activity agent for MSI-High tumors.


Can High-Dose Vitamin C Treat Lung, Pancreatic Cancer?

Cancer researchers in the US are currently studying the effects of treatment combining chemotherapy or radiotherapy with high doses of vitamin C administered intravenously. The first results, focusing on lung cancer and pancreatic cancer -- the two of the disease's most deadly forms -- appear to be encouraging. Vitamin C levels in the blood can be 100 to 500 times higher when administered intravenously, researchers from the University of Iowa, USA, explain in a study published in Redox Biology.


World renowned Surgeon and researcher to lead new Pancreatic Cancer Center At NYU Langone

NYU Langone Medical Center has announced that internationally recognized surgeon and scientist Diane M. Simeone, MD, will join its Perlmutter Cancer Center on March 1 to serve as associate director for translational research and to lead its newly established pancreatic cancer center.Currently director of the gastrointestinal oncology program at University of Michigan's Comprehensive Cancer Center in Ann Arbor, Dr. Simeone has had a long and distinguished career in pancreatic cancer research and treatment. Her laboratory was the first to identify pancreatic cancer stem cells, a discovery that might explain why current drug therapies are ineffective against the disease. She also leads a prolific research program on pancreatic cancer prevention, early detection and therapeutics, and holds major leadership positions with organizations advancing pancreatic cancer research and advocacy worldwide.


"Reduce risk for Pancreatic Cancer by regular use of Aspirin"

Besides what it is prescribed to address for the patients, the regular use of aspirin as researchers found out has a surprising effect. The risk of having pancreatic cancer is reduced in patients who take aspirin regularly.A study conducted in Shanghai, China found out that the risk of having pancreatic cancer is reduced to as much as 50 percent due to regular use of aspirin. However, the researchers stress that the use of aspirin should be prescribed by a doctor as inappropriate use of aspirin can lead to complications.

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PEGPH20 may improve PFS in Pancreatic Cancer

Adding PEGPH20 to nab-paclitaxel and gemcitabine significantly improved progression-free survival among treatment-naive patients with stage IV pancreatic cancer who had high levels of hyaluronan, according to a press release from Halozyme Therapeutics, the developer of PEGPH20.1 Results from a combined analysis of stages 1 and 2 and stage 2 alone of the multicenter, phase 2 HALO 202 ( Identifier: NCT01839487) showed that among patients with high levels of hyaluronan, PEGPH20 improved median progression-free survival by 91% compared with nab-paclitaxel and gemcitabine alone. Median progression-free survival was 8.6 months with PEGPH20, nab-paclitaxel, and gemcitabine vs 4.5 months with nab-paclitaxel plus gemcitabine.

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"MabVax Therapeutics (MBVX) Files IND for Novel Radioimmunotherapy Agent"

MabVax Therapeutics Holdings, Inc.(Nasdaq: MBVX),announces the filing an Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA) for MVT-1075 (177Lu-CHX-A″-DTPA-HuMab5B1),the Company's novel fully human antibody radioimmunotherapy (RIT). Subject to receiving FDA authorization to proceed, MabVax plans to initiate the phase I clinical trial in patients with recurrent pancreatic cancer and other CA19-9 positive malignancies early in 2017. This is the third IND filed by MabVax that builds on the tumor targeting characteristics of the HuMab-5B1 antibody discovered from immune responses of cancer patients vaccinated with the Company's proprietary cancer vaccines.

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"France's Ipsen to buy Merrimack's pancreatic cancer drug, assets in $1 billion deal"

French drugmaker Ipsen SA (IPN.PA) said on Monday it would buy some assets of Merrimack Pharmaceuticals Inc (MACK.O), including pancreatic cancer drug Onivyde, for up to $1 billion, barely a month after the U.S. company stopped a breast cancer drug trial.

The deal would give Merrimack the resources to fund the development of three new compounds targeting pancreatic, lung, and other types of cancers. It would boost Ipsen's portfolio, which has traditionally focused on endocrinology.

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"I Had No Idea I had an Increased Risk for Breast Cancer - Until My Dad Got Pancreatic Cancer"

When Shelby Hasten’s dad was diagnosed with pancreatic cancer in 2014, it’s safe to say her life changed forever. In addition to grappling with the illness of her father, Shelby started down a path that led her to discover she was at an increased risk of developing cancer herself.

A friend of Shelby’s—an ob-gyn nurse practitioner— is the one who let her know that there was, sadly, a connection between the genetics of pancreatic cancer and breast cancer. (According to the American Cancer Society, certain inherited gene mutations can increase your risk for both types of the disease).

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pancreatic tumour tissue development stopped by vitamin a process

Pancreatic ductal adenocarcinoma (PDAC), the most common type of malignancy of the pancreas, is extremely aggressive and very difficult to treat but now scientists suggest vitamin A may have a role to play in tackling the commonest form of pancreatic cancer.

In a new study, researchers from Imperial College London observed that it was possible to switch off pancreatic stellate cells (cells in the immediate tumour environment), potentially preventing the formation of the tissue around the tumour, through a process involving vitamin A

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A u.s. "cancer moonshot" to accelerate cancer research

In January 2016 President Obama announced a “Cancer Moonshot” to “accelerate our understanding of cancer and its prevention, early detection, treatment, and cure” (1). A Blue Ribbon Panel (BRP) of scientific experts was convened to make recommendations to the National Cancer Advisory Board (NCAB), the adviser to the National Cancer Institute (NCI), on research opportunities uniquely poised for acceleration. These recommendations were presented on 7 September 2016 (2). As cochairs of the BRP, we describe our approach, what it produced, and our expectations. The Lustgarten Foundation has funded two of the authors of this article, Dr. Tyler Jacks and Dr. Elizabeth Jaffee.

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PEGPH20 as a potential breakthrough in pancreatic adenocarcinoma

The upcoming HALO 301 is the first-ever biomarker-driven trial in pancreatic adenocarcinoma, and could potentially change the treatment paradigm for the disease.

In an interview with Targeted Oncology, Margaret A. Tempero, MD, director, Pancreas Center, University of California, San Francisco, discusses the start of enrollment for the HALO 301 trial, the importance of a biomarker-driven trial in pancreatic adenocarcinoma, and how tumor microenvironments play a huge role in the disease.

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eus-fna can help doctors manage certain pancreatic lesions more effectively

An endoscopic procedure can improve the outlook for patients with a fairly common type of pancreatic lesion that is challenging to manage and that, if left untreated, can progress to cancer, according to a study in the September issue of GIE: Gastrointestinal Endoscopy, the peer-reviewed journal of the American Society for Gastrointestinal Endoscopy (ASGE).

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pancreatic cancer trial to make tumours more sensitive to treatment

Cancer Research UK launches a first-of-its-kind pancreatic cancer clinical trial to make cancer cells more responsive to chemotherapy and radiotherapy. The trial, which launches* in the UK today, will treat pancreatic cancer patients whose cancer has grown too big to be removed by surgery but has not yet spread to other parts of the body.

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Novel drug therapy kills pancreatic cancer cells by reducing levels of antioxidants

Cold Spring Harbor, NY – Reducing levels of antioxidants in pancreatic cancer cells can help kill them, newly published research reveals, suggesting an entirely new treatment strategy for the notoriously lethal illness, in which less than 5 percent of patients survive 5 years. Although it has become almost a matter of conventional wisdom in popular culture that raising antioxidant levels in the body tends to keep cancer at bay, a team at Cold Spring Harbor Laboratory (CSHL) demonstrates in a series of sophisticated experiments that in the specific context of pancreatic cells on the road to cancer or already in a malignant state, the last thing one wants to do is to raise antioxidant levels.

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Immune System Infighting Explains Pancreatic Cancer's Aggression

NEW YORK, Aug. 25, 2016 /PRNewswire-USNewswire/ -- Internal conflict between cell types explains why the immune system struggles to recognize and attack pancreatic cancer. Curbing this infighting has the potential to make treatment more effective, according to a study led by researchers from NYU Langone Medical Center and its Perlmutter Cancer Center. The Lustgarten Foundation has funded this research.

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$10.4 million awarded for pancreatic cancer research

The National Cancer Institute (NCI) has awarded a $10.4 million, five-year grant to Washington University researchers and physicians at Siteman Cancer Center to lead a national group of experts in collaborative pancreatic cancer research. 

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Metformin may improve survival in pancreatic cancer patients, study suggests

Researchers from the Tisch Cancer Institute of the Icahn School of Medicine at Mount Sinai in New York City have found that patients with type 2 diabetes already taking metformin before a diagnosis of pancreatic cancer had better chance of survival than those on other medications.

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Pancreatic cancer cells find unique fuel sources to keep from starving

Pancreatic cancer cells avert starvation in dense tumors by ordering nearby support cells to supply them with an alternative source of nutrition. This is the finding of a study in cancer cells and mice published August 10 in Nature. The study was led by researchers from NYU Langone Medical Center, the Dana Farber Cancer Institute at Harvard, and the University of Michigan Medical School.

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In cancer, it's back to the future as old treatments make cutting-edge ones more effective

New cancer drugs that unleash the immune system on tumors are all the rage, getting credit for curing former President Jimmy Carter’s advanced melanoma and inspiring tech billionaire Sean Parker to pledge $250 million to cancer research. Behind the excitement, however, is the hard truth that these therapies work in only a minority of patients.

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UCLA Pancreas Tissue Bank

David Dawson, M.D, Ph.D., Associate Professor, Department of Pathology and Laboratory and Jonsson Comprehensive Cancer Center, in the David Geffen School of Medicine at UCLA is Director of the UCLA Pancreas Tissue Bank. Since 2005, the UCLA Pancreas Tissue Bank has accrued a repository of high quality archival pancreas tissues and tumors that are made available to researchers for the purpose of facilitating basic and translational research in pancreatic diseases. These tissue resources allow investigators to confirm promising laboratory results in patient tissue samples and are invaluable tools for the discovery and validation of diagnostic, prognostic or predictive clinical biomarkers.

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Pancreatic cancer resists personalized medicine - what researchers are doing to fight back

A team led by University of Arizona researchers is taking a new, patient-directed approach to treating pancreatic cancer. Rather than relying on conventional cell lines that have defined effective drug targets for other types of cancers, they are creating and sequencing cell lines from a cancer patient's own tissue. Their results, outlined August 4 in Cell Reports, reveal that pancreatic tumors are more varied than previously thought and that drug sensitivity is unique to each patient

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Novel gene-hunting method implicates new culprit in pancreatic cancer

Using an innovative approach to identify a cancer's genetic vulnerabilities by more swiftly analyzing human tumors transplanted into mice, researchers have identified a new potential target for pancreatic cancer treatment, published online in Cell Reports.

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Examining the Relationship Between BRCA and Pancreatic Cancer

Mutations in BRCA1 and BRCA2, most commonly linked with breast and ovarian cancers, are now gaining wider recognition for being associated with pancreatic cancer as well. People with BRCA1 or BRCA2 mutations face a 5 percent risk of getting pancreatic cancer in their lifetime.

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Vitamin D Levels Tied to Survival in Pancreatic Cancer

Important results from a Lustgarten-funded project with Chen Yuan and Brian Wolpin, from the Dana-Farber Cancer Institute in Boston, and colleagues were recently reported in the Journal of Clinical Oncology. Their study examined survival outcomes among 493 pancreatic cancer patients from 1984 to 2008, focusing specifically on their blood levels of 25(OH)D, or Vitamin D, before they were diagnosed with the disease. The researchers found that patients with sufficient prediagnostic levels of Vitamin D had a longer overall survival than those who had insufficient levels of Vitamin D.

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VIDEO: ‘Great promise’ in genetic markers for identifying malignancy in pancreatic cysts

In this exclusive video from DDW 2016, outgoing AGA President Michael Camilleri, MD, from the Mayo Clinic in Rochester, Minn., discusses two abstracts presented during the AGA Presidential Plenary that show promise for using genetic markers to improve the diagnosis of pancreatic cysts.

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ASCO Releases Clinical Practice Guideline on Treatment of Potentially Curable Pancreatic Cancer

ASCO has released a clinical practice guideline on the treatment of potentially curable pancreatic cancer, as reported by Alok A. Khorana, MD, of Cleveland Clinic, and colleagues, in the Journal of Clinical Oncology. The recommendations are based on expert panel systematic review of the literature from 2002 to 2015.

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Microsoft Finds Cancer Clues in Search Queries

Microsoft scientists have demonstrated that by analyzing large samples of search engine queries they may in some cases be able to identify internet users who are suffering from pancreatic cancer, even before they have received a diagnosis of the disease.

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ASCO Annual Meeting: Existing Treatments Used in New Ways - Mixing old and new chemotherapies to treat pancreatic cancer

Researchers found that adding capecitabine to standard treatment with gemcitabine helped patients live longer. Gemcitabine is the chemotherapy typically used to treat pancreatic cancer after surgery. Capecitabine is a chemotherapy most commonly used to treat breast and colorectal cancers. Adding capecitabine is a new approach to treating pancreatic cancer. Both gemcitabine and capecitabine are available as generic drugs.

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Chemotherapy Combination After Surgery Improves Survival in Pancreatic Cancer

Adding capecitabine to gemcitabine nearly doubled five-year overall survival (OS) rates compared with gemcitabine alone for patients with pancreatic cancer whose tumors had been surgically removed, as demonstrated in a Phase 3 European trial. The median overall survival (OS) was 28 months with the combination chemotherapy regimen compared to 25.5 months with gemcitabine alone, an improvement in survival of 18 percent.

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Momenta Pharmaceuticals Announces Presentation of Final Data from Phase 1 Trial of Necuparanib in Patients with Pancreatic Cancer at ASCO

Results from a Phase 1 trial evaluating necuparanib, a novel drug, in combination with the standard of care, nab-paclitaxel (Abraxane) and gemcitabine, in patients with advanced metastatic pancreatic cancer ( Identifier NCT01621243), were presented last week at the 2016 ASCO annual meeting.

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ASCO 2016: Rucaparib Shows Clinical Benefit in BRCA-Mutated Pancreatic Cancer

The targeted PARP inhibitor rucaparib, which has demonstrated robust clinical activity in patients with ovarian cancer who have a BRCA mutation, also showed promise in previously treated patients with pancreatic cancer who have the mutation (about 9%), according to results from a Phase II clinical study presented at the 2016 ASCO Annual Meeting.

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96 % of early stage pancreatic cancer patients detected in a clinical validation study with a North American sample cohort. Second study validates Immunovia´s IMMray™ PanCan-d test for early detection of pancreatic cancer

Using the proprietary IMMray™ technology platform and a biomarker signature, Immunovia’s blood test has been able to discriminate between pancreatic cancer patients with stage I, II, III, and IV has been derived from clinical studies covering about 2500 patient samples in two continents.

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Let's Win Launches!

The Lustgarten Foundation is proud to support the initiative Let's Win , the first-ever online community sharing new, innovative science-driven treatments for Pancreatic Cancer which launched this May!

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THE IMPROVISATIONAL ONCOLOGIST: In an era of rapidly proliferating, precisely targeted treatments, every cancer case has to be played by ear.

The Lustgarten Foundation’s Distinguished Scholar, Bert Vogelstein, M.D., a cancer geneticist at Johns Hopkins University, explains in the NY Times article his commitment to finding a treatment that can be effective and less expensive for several cancers, including pancreatic cancer. He discusses that despite our genetic diversity, targeting the 12 core pancreatic cancer pathways rather than the individual gene mutations involved in pancreatic cancer will ultimately impact how cancer is observed and treated.

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AACR Congratulates Newest National Academy of Sciences Members

The American Association for Cancer Research (AACR) congratulates its 10 members who have been elected to the National Academy of Sciences, including Hidde Ploegh, Ph.D., a Research Investigator and Kenneth Kinsler, Ph.D. (Early Detection Initiative) which have been elected are both Lustgarten Foundation grant recipients for their research in pancreatic cancer.

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Study Finds Benefit of Surveillance for Pancreatic Cancer in High-Risk Individuals

"As reported by Vasen et al in the Journal of Clinical Oncology, surveillance for pancreatic ductal adenocarcinoma in high-risk individuals appears to be of benefit in individuals at risk due to CDKN2A mutation, with the advantage being less clear among individuals at risk due to familial clustering of pancreatic cancer."

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10 Things Cancer Experts Do To Avoid Getting The Disease

There's really no way to soften this: About 1,685,210 cancer cases are expected to be diagnosed in 2016, according to the American Cancer Society, and almost 600,000 Americans will die from these dread diseases. But there are many things you can do to lower your chances of becoming a statistic. We asked top oncologists and other cancer specialists for advice.

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Genomic Analyses Identify Molecular Subtypes of Pancreatic Cancer

Promising research published in Nature demonstrates that there are four distinct subtypes of pancreatic cancer, and each has its own prognosis and molecular characteristics that may predict its responsiveness to certain therapies.

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BRCA Clinics Expand Further Beyond Breast Cancer - New thinking on pancreatic, prostate cancer treatment; centers consolidate patient care under one roof

“A clinic at University of California, San Francisco has set out to specifically treat patients with genetic mutations in BRCA1 and BRCA2, but not just for breast cancer. The mutations are widely recognized as inheritable causes of breast and ovarian cancers, but less well known for their roles in causing pancreatic, prostate and some other cancers that affect both men and women."

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12 Things You Must Know If Pancreatic Cancer Runs in Your Family

“One of our Research Investigators, Dr. Alison Klein (Johns Hopkins University) offers insight into how pancreatic cancer can run in families, and what to do to protect yourself."

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Pancreatic Cancer Ecosystem and Vitamin D

The Lustgarten Foundation's board member, Anne Glauber shares a personal journey as it relates to her own treatment of ‪#‎PancreaticCancer‬ with synthetic vitamin D and the micro-environment of the actual disease.

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Stand Up To Cancer, Cancer Research UK, and The Lustgarten Foundation Fund Team with $12 million

The Stand Up To Cancer – Cancer Research UK –Lustgarten Foundation Dream Team of top cancer researchers from the United States and the United Kingdom was named here today to launch a fresh attack on pancreatic cancer, one of the deadliest forms of cancer on both sides of the Atlantic.

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FDA Approves New Treatment for Advanced Pancreatic Cancer

The U.S. Food and Drug Administration today approved Onivyde (irinotecan liposome injection), in combination with fluorouracil and leucovorin, to treat patients with advanced (metastatic) pancreatic cancer who have been previously treated with gemcitabine-based chemotherapy.

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Sharing Pancreatic Cancer Treatment Information - A Lifeline

The Lustgarten Foundation's board member, Anne Glauber shares her own treatment as a lifeline for other patients with ‪‎Pancreatic Cancer‬.

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Pancreatic Cancer Deserves Research Investment

In the battle against pancreatic cancer, every bit of medical progress is good news. This is one of the deadliest cancers of all.

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For the Most Lethal Cancer: Find the Best Science

The Lustgarten Foundations’ board member, Anne Glauber explains how living with pancreatic cancer has some blessings, creating a “life of love”, as well as meeting scientists and doctors committed to changing the course of this disease. “Although the past 40 years have given us very few (and no long-term) treatments for pancreatic cancer, there is now new progress from a number of exceptional scientists willing to focus on these challenges.”

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Naperville Pancreatic Cancer Research Walk

The 5th Annual Naperville Pancreatic Cancer Research Walk brought together a community of people joining the fight against the disease.In the past four years, this walk has raised over $166,000 for critically needed research. This year had the most walkers and donations to-date.

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Congress Must Pass 21st Century Cures Act Now

This is an incredibly exciting time in biomedical research[...]At a time of seemingly perennial gridlock in Washington, the U.S. Congress has emerged as a surprising catalyst for such change. A large bipartisan effort over the past year has identified ways to speed the availability of safe and more effective treatments for patients by taking full advantage of the latest science. That is what underpins the 21st Century Cures Act (HR 6) now making its way through Congress.

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Toward Blood-Based Cancer Detection

Dr. Bert Vogelstein, a Lustgarten Foundation Distinguished Scholar and the head of our Early Detection Initiative, is quoted in an article in The Scientist that highlights the future and hope of the “liquid biopsy”, or blood sample, as a means to detect cancer before clinical symptoms occur.

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Tiny Particles in Blood Useful for Early Diagnosis of Pancreatic Cancer

Dr. Raghu Kalluri, a Lustgarten Foundation-funded scientist at MD Anderson Cancer Center, has discovered that a protein called GPC1 is highly expressed on the surface of small, cancer-produced structures called “exosomes”. GPC1-expressing exosomes are released and detectable in the blood, which means they have the potential to become a clinical cancer biomarker.

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Study Identifies Multiple Genetic Changes Linked to Increased Pancreatic Cancer Risk

One of our own Research Investigators, Alison Klein at Johns Hopkins University School of Medicine, discovered four new genetic variations that may increase the risk for Pancreatic Cancer if it is present in a person's genome, or genetic blueprint.

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PEGPH20 Comibation Doubles PFS in HA-High Pancreatic Cancer

"Recent clinical work by one of our outstanding ‪grantees‬, Dr. Sunil Hingorani, has shown that, "the addition of the enzyme PEGPH20 to standard nab-paclitaxel and gemcitabine improved progression-free survival (PFS) by 4.9 months compared with the two agents alone in untreated patients with advanced ‪pancreatic‬ ‪cancer‬ with high expression levels of hyaluronan (HA), according to interim findings from a phase II study presented at the 2015 ‪ASCO‬ Annual Meeting."

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Antibody Fragments Expand What PET Imaging Can 'See' In Mice

“Lustgarten-funded researchers Dr. Hidde Ploegh and Dr. Ralph Weissleder have designed a more sensitive and precise imaging technique to detect and monitor pancreatic tumors.

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Small Study Shows Genetic Biomarker May Predict Cancer Patients' Response to Immunotherapy Drug

Research findings published in the New England Journal of Medicine and funded in part by The Lustgarten Foundation show promise leveraging certain immunotherapy drugs for a small subset of pancreatic cancer patients where standard therapies have failed.

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Finding My Treatment For Pancreatic Cancer

The Lustgarten Foundation’s board member, Anne Glauber, explains the innovative treatment she is receiving for her stage IV pancreatic cancer.

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The Next Shock After a Pancreatic Cancer Diagnosis: Where Are the Treatments?

The Lustgarten Foundation's board member, Ann Glauber, is telling her story about being diagnosed with stage IV pancreatic cancer and her frustration with the lack of treatment options available.

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A Walk to Remember: Raising Awareness About Pancreatic Cancer

"Pancreatic cancer was something I knew little about until this "silent killer," as it is known, came into our lives with devastating speed and took someone we loved, so much, away, so quickly."

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Dr. Carl June offers pancreatic cancer patients revolutionary new immunotherapy

With a jointly funded $1.1 million grant provided by the Lustgarten Foundation and the Cancer Research Institute, scientists at the University of Pennsylvania will begin clinical testing of a new form of immunotheraopy, which they anticipate could dramatically improve patient health.

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2015 Ruth Leff Siegel Award

The pancreas Center is announcing a call for nominations for the third annual, 2015 Ruth Leff Siegel Award.

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$12 Million translational research grant announced

Cancer Research UK  and The Lustgarten Foundation join with SU2C to fund new Pancreatic Cancer Dream Team.

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New Clinical Trial

New immunotherapy clinical trial begins with support from SU2C and The Lustgarten Foundation Pancreatic Cancer Dream Team. 

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Lustgarten foundation Investigators

Multi million dollar grants allow scientists to dedicate more focus to identifying new breakthroughs in pancreatic cancer research and accelerating a path to a cure.  

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Thanks to private funding, 100% of every dollar donated to the Lustgarten Foundation goes directly to pancreatic cancer research.

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